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Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering Free
Yi Yang1,†, Kepin Wang1,†, Han Wu1, Qin Jin1, Degong Ruan1, Zhen Ouyang1, Bentian Zhao1, Zhaoming Liu1, Yu Zhao1, Quanjun Zhang1, Nana Fan1, Qishuai Liu1, Shimei Guo1,2, Lei Bu3, Yong Fan4, Xiaofang Sun4, Xiaoping Li1,*, and Liangxue Lai1,5,*
1Key Laboratory of Regenerative Biology of the Chinese Academy of Sciences and Guangdong Provincial Key Laboratory of Stem Cells and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China
2School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
3Leon H Charney Division of Cardiology, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
4Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
5Jilin Provincial Key Laboratory of Animal Embryo Engineering, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China *Correspondence to:Liangxue Lai, E-mail: lai_liangxue@gibh.ac.cn; Xiaoping Li, E-mail: li_xiaoping@gibh.ac.cn
J Mol Cell Biol, Volume 8, Issue 2, April 2016, 174-177,  https://doi.org/10.1093/jmcb/mjw008

Type 1 diabetes (T1D) is a lifelong (chronic) disease and a major health problem throughout the world. This disease can be treated by either insulin injection or islet transplantation. Islet transplantation is considered as a better treatment for T1D patients, because islets can produce and release insulin at the appropriate time, resulting in tight blood glucose control. However, islet transplantation is performed only for brittle T1D patients due to lack of sufficient donors: only 1 of 333 patients with insulin-dependent diabetes mellitus (IDDM) can obtain human islets (Frank et al., 2005).


Volume 8, Issue 2
April 2016